Contact an Account ManagerSimultaneous determination of clarithromycin and 14(R)-hydroxyclarithromycin in plasma and urine by HPLC with electrochemical detection
Summary
Type: HPLC
Application #: 103620
Catalog#: 720013.46 - MN HPLC Column, Nucleosil C8, 100A, 5um, 4.6x250mm
Detection: electrochemical, screening electrode +0.5V, working electrode +0.78V
Conditions: eluent: acetonitrile - methanol - water ((39:9:52, v/v) containing 0.04M NaH2PO4, adjusted to pH 6.8 with NaOH
flow rate 1.2 - 1.4ml/min
Authors: Chu S-Y
Source: J Chromatogr 571 (1991) 199 - 208
Details
Legend: Fig. 2. Chromatograms from plasma samples, (A) normal human plasma (NHP), (B)
NHP spiked with clarithromycin (I), 14-hydroxyclarithromycin (II), internal
standard (III) and descladinosylated clarith